Scientific Programme
Day 1 – 25 August 2022
| 15:00-15:10 | Opening |
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| 15:10-16:40 | Plenary session Congress Hall Chair: László Buday |
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| 15:10-15:45 | PL-1 László Nyitray Forty year adventure in the world of proteins |
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| 15:45-16:20 | PL-2 Ferenc Gallyas Jr. Mitochondrial and PARP-mediated mechanisms in the cell death process |
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| 16:20-16:40 | Bio Science award talk András Tálas, Dorottya Simon BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors |
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| 16:40-17:00 | Coffee break |
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| 17:00-18:00 | Poster discussion I. Jump to List of posters |
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| 18:15- | Welcome reception |
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Day 2 – 26 August 2022
| 09:00-09:30 | Plenary session Congress Hall Chair: László Buday |
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| 09:00-09:30 | PL-3 András Nagy A way to generate safe and global source for off-the-shelf therapeutic cell products |
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| 09:30-11:10 | Molecular signaling, cell-cell communication, cell death and differentiation
Chair: László Buday |
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| O-01 Orsolya Kapuy Autophagy is controlled with a unique regulatory network upon cellular stress |
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| O-02 Zsolt Sarang Regenerating skeletal muscle compensates for the impaired macrophage functions leading to normal muscle repair in retinol saturase null mice |
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| O-03 Sarolta Tóth PMCA4b plasmamembrane calcium pump regulates cell polarization and lumen formation |
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| O-04 Ilka Keller The role of SMTNL1 in the physiological and pathological functions of endometrium |
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| O-05 Fadi Ramadan Effect of desethylamiodarone on mitochondrial mechanisms and cyclooxygenase-2 in breast cancer cell lines |
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| 11:10-11:30 | Coffee Break |
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| 11:30-13:10 | Regulation of gene expression, regulatory RNA, epigenetics Chair: Tamás Arányi |
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| O-06 István Szatmári RUNX3 dependent gene expression analysis with bulk and single cell RNA sequencing |
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| O-07 Ágnes Tantos Connection between HOTAIR, Ezh2 and Tks4 in Epithelial Mesenchymal Transition |
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| O-08 Mihály Kovács Intracellular condensation patterns of single-stranded DNA binding proteins reveal novel roles in cellular stress response |
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| O-09 Zoltán Ivics Non-viral engineering of therapeutic cells with the Sleeping Beauty transposon system |
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| 12:50-13:10 | Bio Science Nándor Nagy, Zoltán Hegyi Everything is possible: pushing the boundaries of automated cell imaging and genetic engineering |
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| 13:10-14:00 | Lunch |
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| 14:00-14:20 | Bio-center Nyíri Kinga Octet® BLI Label-Free Detection Systems for Biomolecular Interactions Analysis |
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| 14:20-15:40 | Protein structure, function and modeling Chair: László Nyitray |
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| O-10 Zsuzsánna Réthi-Nagy STABILON motif enhances gene expression and protein stability |
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| O-11 Attila Borics The role of correlated motions of conserved motifs and the binding modes of agonists in the activation mechanism of g protein-coupled receptors |
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| O-12 Zoltán Lipinszki Novel mitotic targets of the PP5 phosphatase |
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| O-13 Csaba Hetényi Exploration of water structure of protein-ligand complexes |
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| 15:40-16:00 | Coffee Break |
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| 16:00-17:00 | Protemics Chair: Éva Csősz |
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| O-14 Éva Csősz Multi-omics analyses in diabetes and atherosclerosis |
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| O-15 Aladár Pettkó-Szandtner Examination of molecular signaling by proteomics |
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| O-16 Ádám Pap Mass spectrometric analysis of mucin-type O-glycopeptides |
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| 17:00-18:00 | Poster discussion II. Jump to List of posters |
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| 19:30-23:00 | Banquet | |
Day 3 – 27 August 2022
| 09:00-11:00 | Molecular basis of disease and therapy, stem cells, immunity and inflammation
Chair: László Homolya |
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| O-17 Endre Kristóf Availability of abundant thiamine determines efficiency of beige differentiation and thermogenic activation in human neck area derived adipocytes |
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| O-18 Krisztina Kovács New therapeutic approaches in the treatment of triple-negative breast cancer |
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| O-19 Loretta László The role of Tks4 scaffold protein in tumor biology |
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| O-20 Zsolt Balogi Tumor lipids towards lipid based therapie |
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| O-21 Angéla Békési Drug-specific differences in genomic uracil patterns and mutagenic processes induced by thymidylate synthase inhibitors |
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| O-22 László Homolya Fine-tuned modulatory effect of microglia on neurite generation and differentiation of human neural progenitor cells |
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| 11:00-11:20 | Coffee Break |
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| 11:20-13:00 | Translational medicine & Lipids and membranes Chair: Péter Bay |
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| O-23 Péter Bay Repurposing of clinically available PARP inhibitors in acute COVID-19 disease |
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| O-24 Rita Lózsa Mismatch repair corrects oxygen-dependent DNA defects |
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| O-25 Zoran Marinović Spermatogonial stem cells as a potential target for genome editing and genetic improvement of fish stocks |
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| O-26 Okba Hatem Fatty acid composition and variability of commercially available plant-based drinks |
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| O-27 Farkas Sarnyai Different metabolism and toxicity of trans fatty acids, elaidate and vaccenate compared to cis-oleate in HepG2 cells |
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| 13:00 | Closing | |
| 13:20- | Farewell Lunch |
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List of posters
| P-01 | Margita Márton A systems biological analysis of the feedback loops inside ER stress-induced PERK pathway |
| P-02 | Aliz Szabo Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases |
| P-03 | Balázs Veres Alteration of lipidomic profile in mice lacking cyclophilin D |
| P-04 | Andrea Guba Amino acid and biogenic amine analysis of tear and saliva samples in diabetes and oral cancer |
| P-05 | Zoltán Szeltner Biological approaches in the characterisation of telomere-like G4 structures with full or partial 5-hydroxy-2’-deoxyuridine substitution |
| P-06 | Éva Schád Comparison of the RNA interactome of KMT2D and KMT2F |
| P-07 | Viktor Vedelek Comprehensive search for regulatory motifs of gene expression during spermatogenesis |
| P-08 | Márton Szabó Diet-induced hypercholesterolemia leads to cardiac dysfunction and alterations in the myocardial proteome |
| P-09 | Tibor Rauch DNA methylation governed expression of alternative TEAD4 promoter |
| P-10 | Balázs Kőszegi Effect of AP39, a H2S donor molecule, on the expression of ageing-related genes in PolgA(D257A) mice |
| P-11 | Edina Pandur Effect of fractalkine on the receptivity of iron deficient HEC-1A endometrium cells |
| P-12 | Eszter Vámos Effect of KRP-6, a novel MIF tautomerase inhibitor on macrophage activation and mitochondrial function |
| P-13 | Rauan Sakenov Effect of SMIFH2 on functional dynamics of FH2 Domain of DAAM (Drosophila): Study on Mechanism of Action of SMIFH2 against actin polymerization activity of FH2 domain of DAAM |
| P-14 | Gergely Jánosa Effect of vitamin D on the thapsigargin caused dysregulation of iron homeostasis in neuroblastoma cells |
| P-15 | Eszter Holub Effects of thymidylate synthase inhibitors on cell cycle and cell viability |
| P-16 | Bence Hajdú Fine-tuning of PP2A-ULK1-mTOR regulatory triangle is crucial for robust autophagic response upon cellular stress |
| P-17 | Orsolya Mózner Generation of cell lines that produce fluorescent vesicles containing a coronavirus antigen protein on their surface |
| P-18 | Dávid Szüts Genome-level analysis of DNA damage tolerance pathways in a human cell line |
| P-19 | Bendegúz Szabó Genomic rearrangements in BRCA1(-/-) PCNA (K164R/K164R) mutant cell lines |
| P-20 | Fanni Alexandra Szalmás Histological analysis of protein arginine methyltransferase 5 in human lung tumors |
| P-21 | Balazs Debreceni Homocysteine-induced cell death in wrl-68 cell culture |
| P-22 | Róbert Király Identification of human TG4 substrates and protein interaction partners in saliva |
| P-23 | Bianka Csaholczi Identification of potential interaction partners of transglutaminase 2 in endothelial cells |
| P-24 | Zoltán Kónya Identification of potential protein phosphatase-1 and -2A modulators via high throughput screening |
| P-25 | Nikolett Sándor Identifying specific hsp70-lipid interactions |
| P-26 | Adrienn Horváth Interaction of dithiothreitol-induced unfolded protein response and vitamin D in a neuronal cell model |
| P-27 | Eszter Éva Kálmán Investigation of the interactions of the circadian rhythm and cell cycle |
| P-28 | Maysaa Ali Investigation of the phagocytic capacity of C2C12 myoblast cells |
| P-29 | Viola Bagóné Vántus Investigation the effects of the PARP inhibitor Talazoparib in a TNBS-induced Inflammatory Bowel Disease Mice Model |
| P-30 | Andrea Kiss LIM kinase 2 is a novel phosphorylation-dependent inhibitor of protein phosphatase-1 |
| P-31 | Gábor Hajdú LRO-dependent stress and immune defenses require the pgp-2 ABC transporter in C. elegans |
| P-32 | Erdenetsetseg Nokhoijav Metabolomics analysis of serum in obesity and type 2 diabetes |
| P-33 | Rita Sinka Microtubule organizing centers contain testis-specific γ-TuRC proteins in spermatids of Drosophila melanogaster |
| P-34 | Ajneesh Kumar Network analysis of proteomics data in human atherosclerosis |
| P-35 | Edit Szabó New fluorescence-based high-throughput functional assay of the ABCB1 multidrug transporter |
| P-36 | Bence Kiss New short fusion peptide-based immunization platforms for SARS-CoV-2 |
| P-37 | Sára Széles Nuclear regulation of myosin phosphatase by mg2+-dependent protein phosphatase 1b in tumor suppressor signaling pathways |
| P-38 | Judit Vágó Optimisation of the chondrifying chicken limb bud-derived micromass cell culture system |
| P-39 | Barbara Brandt Overcoming temozolomide resistance by inhibiting protein neddylation in glioblastoma cell lines |
| P-40 | Nastaran Tarban Regenerating skeletal muscle compensates for the impaired macrophage functions leading to normal muscle repair in retinol saturase null mice |
| P-41 | Enikő Jávor-Hocsák Regulation of the ATF4-MKP-1-MAPK-mitochondrial damage-cell death pathway by PARP-1 in oxidative stress |
| P-42 | Ádám Ungvári Smoothelin-like 1 protein and its derivative enhances reversal of insulin resistance in C2C12 cell line |
| P-43 | Henrietta Hóf Stabilization of LOTUS, a possible stimulant of nervous system regeneration |
| P-44 | Tamás Takács Structural insights into the pSer/pThr dependent substrate recognition of the SHP2 tyrosine phosphatase in insulin signaling and beyond |
| P-45 | János Juhász Studying growth characteristics of yeast strains |
| P-46 | Balint Nagy Substrate interactions and in situ chemical modification of human 2-oxoglutarate dehydrogenase enzyme complex components |
| P-47 | Peter Balázs Jakus Synthesis and evaluation of new class of MIF-inhibitors in activated macrophage cells, and in experimental septic shock in mice |
| P-48 | Dóra Halmi The cytoprotective effect of kynurenic acid against simulated ischemia/reoxygenation-induced damage of cardiac cells |
| P-49 | Ramóna Pap The effect of lutein in glutamate-induced neurotoxicity in SH-SY5Y cells |
| P-50 | Job Kola The effects of CXCL1 on intestinal motility |
| P-51 | Krisztina Tar The mitochondrial fission protein DRP1 controls neuronal differentiation and is involved in Huntington’s disease neuropathology |
| P-52 | Arijit Sarkar The role of correlated motions of conserved motifs and the binding modes of agonists in the activation mechanism of g protein-coupled receptors |
| P-53 | Isotta Sturniolo The role of poly(adp-ribosyl)ation in shaping the phenotype of tumor-associated macrophages in a 3d spheroid model |
| P-54 | Marianna Holczer The study of autophagy-dependent survival in endoplasmic reticulum stress |
| P-55 | Kitti Andreidesz Trans fatty acids aggravate the hypomethylation of line-1 retrotransposon DNA In an environmental carcinogen model |