Annual Meeting of the Hungarian Biochemical Society

29-31 August, 2024, Budapest, Hungary

Final Programme

Day 1 – 29 August 2024

15:00-15:10 Opening
15:10-16:20 Plenary session
Congress Hall

Chair: László Buday
15:10-16:00 PL-1
György Keserű
Mapping protein-protein interaction surfaces by photoactivable molecular fragments
16:00-16:20 Bio Science award talk
Áron Szabó
LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models
16:20-16:35 Company lecture of Kromat Kft.
Éva Csősz

Complex analysis of obesity and type 2 diabetes moonlights Olink's proximity extension assay as a method of choice in multiomics setup
16:35-16:50 Company lecture of Molnár-Institute
Imre Molnár

Speeding up research in Biochemistry by Modeling HPLC
16:50-17:15 Coffee break
17:00-18:00 Poster discussion I.
Jump to List of posters or Jump to poster discussion I. (odd number)
18:15- Welcome reception

Day 2 – 30 August 2024

09:00-09:30 Plenary session
Congress Hall

Chair: László Virág
09:00-09:30 PL-2
József Tőzsér
Structure, function, inhibition and resistance development of sars-cov-2 main protease (MPRO). what is common with retroviral proteases?
09:30-10:50 Molecular signaling, cell-cell communication, cell death and differentiation
Chair: Zoltán Lipinszki
O-01
Zoltán Lipinszki

Exploring the Substrate Recognition Mechanism of Protein Phosphatase 4 Reveals Novel Functions of the Enzyme in DNA Damage Repair
O-02
Krisztina Tar

Can Manipulating Mitochondrial Dynamics Enhance Neuronal Differentiation?
O-03
Endre Kristóf

Upregulation of Inhibitor of DNA Binding 1 and 3 is important for efficient thermogeninc response in human adipocytes
O-04
Virág Vas

A comprehensive study from EMT regulation to cancer biomarker discovery: "Tyrosine kinase substrate with four SH3 domains" in focus
10:50-11:10 Coffee Break
11:10-12:30 Regulation of gene expression, regulatory RNA, epigenetics
Chair: Mihály Kovács
O-05
Mihály Kovács

Subcellular rearrangements of bacterial single-stranded DNA binding (SSB) protein condensates indicate roles in stress response and cell proliferation
O-06
Ágnes Tantos

Competing endogenous RNA networks in different cancers
O-07
Pantazi Vasiliki

K63-linked ubiquitylation of RNAPII in response to DNA Double-Strand Breaks drives repair regulation
O-08
Jacksi Mevan

The role of EZH2 in TKS4-deficient colorectal carcinoma cells
12:30-13:30 Lunch
13:30-14:50 Protein structure, function and modeling, proteomics
Chair: Ferenc Erdődi
O-09
Orsolya Tőke

Pressure denaturation of proteins
O-10
Zoltán Kónya

Characterization and analysis of protein phosphatase-1 and -2A modulators identified by high throughput screening
O-11
Boglárka Zámbó

Proteome-wide affinity survey of DNA-protein interactions: A case study on the erythroid-specific promoter of ATP2B4 gene and GATA1 mutations
O-12
Gergő Gógl

The non catalytic epsilon DNA polymerase subunit is an NPF motif recognition protein
14:50-15:10 Coffee Break
15:10-16:30 Bioinformatics, synthetic biology, genome engineering, biotechnology
Chair: Zoltán Ivics
O-13
Zoltán Ivics

Advances in non-viral engineering of therapeutic cells with the Sleeping Beauty transposon system
O-14
Orsolya Kapuy

Re-wiring the AMPK-ULK1 regulatory connection at the service of periodic autophagy induction
O-15
Regina Martinek

Comprehensive investigation of the mutagenic potential of six pesticides classified by IARC as probably carcinogenic to humans
O-16
István Hajdú

Beta secretase 1 Recruits Amyloid beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta¬amyloid Plaque Formation
16:30-16:45 Introduction of the FEBS Junior Section Hungary
Chair: Virág Vas
16:45-18:00 Poster discussion II.
Jump to List of posters or Jump to poster discussion II (even number)
18:00- Gala dinner

Day 3 – 31 August 2024

09:00-10:40 Molecular basis of disease and therapy, stem cells, immunity and inflammation
Chair: Zsuzsanna Izsvák
O-17
Zsuzsanna Izsvák

HERVHLin protects human genome from mutagenic retroelements by rewiring the conserved LIN28A/let7 pathway in the early embryo
O-18
Flóra Szeri

Alkaline phosphatase activity correlates with circulatory mineralization factors upon aging in mice and human
O-19
Rini Arianti

Solute carrier transporters-mediated amino acids uptake is essential for thermogenic activation of human primary adipocytes
O-20
Andrea Kocsis

SARS-CoV-2 Nucleocapsid Protein Is Not Responsible for the Over-Activation of Complement Lectin Pathway
O-21
Yousif Qais Muhsin Al-Khafaji

Short-term thiamine deficiency altered transcriptomic profile of human deep cervical-derived adipocytes
10:40-11:00 Coffee Break
11:00-12:20 Translational medicine & Lipids and membranes
Chair: György Vereb
O-22
György Vereb

Chimeric antigen receptors (CAR) in the treatment of solid tumors: lessons from HER2+ preclinical models
O-23
József Prechl

A truly quantitative antibody serological assay utilizing double-titration on antigen microspots
O-24
Mohammed Maki

Anaerobic glycolysis and MCT1inhibition via diclofenac lead to tumorigenesis regression, ROS accumulation through links intracellular acidification and OXPH in K562 erythroleukemia
O-25
Tibor Pankotai

Proteogenomics reveals varying levels of intra-patient heterogeneity in melanoma metastases
12:20 Closing
12:40- Farewell Lunch

List of posters

P-01Kristóf Gui
The analysis of the classical and extended synergy transcription programs in macrophages and in epithelial-like tumor cells in the presence and absence of the transcription factor BACH1
P-02Botond Engel
The mutagenic outcome of translesion replication at DNA adducts depends on polymerase choice
P-03Valentina Madár
Exploring multicellular growth of yeast
P-04Judit Tóth
dUTPase modulates mycobacterial homologous recombination through interaction with AdnAB
P-05Ankita Murmu
Intercellular communication and CD8+ T-cell trajectory analysis in ovarian cancer tissues
P-06Anna Zichy
Mapping and validation of structural variants in lung cancer for enhanced understanding of tumor development
P-07Tamás Takács
Orthosteric inhibitors targeting SHP2: structural insights and challenges
P-08Eszter Vámos
The effect of trimethylamine, a metabolite of gut microbiota on the metabolic reprogramming of M1 macrophages
P-09Nikolett Nagy
Moonlighting role for dUTPase: establishing a viable mammalian cell line with high uracil DNA levels
P-10Bence Farkas
The dominant form of the C1 inhibitor R444C variant causing type II hereditary angioedema is its covalent adduct with serum albumin explaining elevated levels
P-11András Zeke
Analyzing redox features of proteins based on AlphaFold2 models
P-12Melinda Rostás
Loss of Mer receptor tyrosine kinase attenuates adipocyte hypertrophy and leads to enhanced thermogenesis in mice exposed to high-fat diet
P-13Péter Tóth
Cell sorting based method for identifying CRISPR knock-in clones
P-14Kriszinta Rubina Vass
Recombinant production and characterization of human alpha-keto acid dehydrogenase complex subunits and their disease-relevant variants
P-15Balázs Csoma
Prime editing: advancing the frontiers of genetic engineering
P-16Ilka Keller
Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance
P-17Zsuzsanna Biczók
A study on the reduction of self-complementarity in the prime editing RNA
P-18Károly Hegedűs
Estimating efficiency of immunosuppressive therapy in heart transplant patients
P-19Bálint Csörgő
Repurposing CRISPR-Cas3 systems for probing phage-host interactions
P-20Eszter Holub
Key factors and consequences of drug induced genomic cytosine deamination
P-21Balázs Ligeti
ProkBERT: genomic language models for understanding the microbiome
P-22Alexandra Sándor
Development of an induced pluripotent stem cell-based organoid model for investigating the molecular mechanisms of cerebellar ataxia
P-23Csaba Kiss
Investigating the role of non-coding genetic variants in colorectal cancer through single-cell multiomics analysis
P-24Edit Szabó
Genetic variants of the human thiamine transporter (SLC19A3, THTR2) - potential relevance in type 2 diabetes mellitus
P-25Ágnes Becsei
Detecting uracil in DNA with nanopore sequencing
P-26Katalin Vincze
Exploring the neurological impact of type 2 diabetes in induced pluripotent stem cell derived neuronal progenitors and neurons
P-27Beáta Vértessy
Artificial Intelligence-based search for new enzymes to degrade polluting hydrocarbons
P-28Hédi Maczelka
Developing a novel endothelial dysfunction model using pluripotent stem cell-derived endothelial cells for extracellular matrix recellularisation
P-29Dániel Molnár
Antibacterial action of membrane-incising peptide lamellae
P-30Zita Bognár
Effect of Desethylamiodarone on mitochondrial mechanisms in breast cancer cell lines
P-31Dávid Kovács
Triglyceride acyl length drives lipolysis and adipocyte metabolism
P-32Ádám Ungvári
Myosin phosphatase promotes insulin-senitizing mechanisms in C2C12 muscle cells
P-33Mihály Józsi
Functional characterization of complement Factor H CCP19-20 variants with a set of host-derived and microbial ligands
P-34Viktória Jenei
Immunological characterization the different forms of necrotic cell death
P-35János András Mótyán
Structure-based identification of interacting partners of the human retroviral-like aspartic protease 1 (ASPRV1)
P-36Renáta Bíró
ARHGAP25 has an anti-inflammatory role in the imiquimod-induced psoriasis mouse model
P-37Kiarie Irene Wanjiru
Inhibition profiling of integrase strand-transfer inhibitors and the capsid inhibitor against HIV-2, and exploration of factors associated with viral latency
P-38Bálint Jezsó
Phase separation and cytoplasmic granulation by single-stranded DNA binding protein 1 (SSB1) delineate new mechanisms of cellular stress response
P-39Éva Gráczer
Dissecting the cellular effects of beta-actin mutations causing non-muscle actinopathies
P-40Zoltán Ódor
Utilizing NanoFlare gold nanoparticles for dynamic monitoring of gene expression and cellular differentiation in colorectal cancer cells
P-41Mária Golda
Investigation of the substrate specificity of human retroviral-like aspartic protease 1 (ASPRV1)
P-42Viktória Tisza
CHD1 deletion in prostate cancer and its impact on PARP inhibitor sensitivity
P-43Kriszinta Rubina Vass
NMR structural analysis of the lipoyl domain of the hKGDHc-E2 protein
P-44Petra Körmendi
Crosstalk of LKB1- and PKA-dependent signaling pathways in the regulation of hepatocyte polarity
P-45Dávid Szakács
Interaction of complement C3b with factor H family proteins
P-46Seo Mizuki
Transferrin receptor-mediated iron uptake is required for thermogenic activation in human cervical derived adipocytes
P-47Dávid Szakács
Annexin A2 is a ligand for complement factor H, FHL-1 and FHR proteins
P-48Mustafa Abdulkareem
Investigating the role of RNA binding in the cellular function of KMT2D
P-49Mónika Ágnes Szütsné Tóth
Structure-function coordination in the SALS protein
P-50Otília Tóth
Expression of dUTPase in mouse postnatal development
P-51Mónika Ágnes Szütsné Tóth
Structural analysis of the EB1 protein
P-52Tamás Orbán
Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia
P-53Mohamad Mahfood
Expression of myosin phosphatase in breast cancer
P-54Viktória Perey-Simon
Role and effect of uracil metabolism on zebrafish embryonic development
P-55Csaba Magyar
MD simulation analysis of heterodimeric mutual synergistic folding proteins
P-56Laura Vizkeleti
Functional understanding Septin9 intronic DNA methylation and its impact on colorectal cancer development and diagnosis
P-57Rita Hirmondó
Do Mycobacteria really have no actin? Characterization of a potential Mbl protein
P-58Tamás Arányi
Hepatocyte-specific DNMT3A and DNMT3B knockout mice develop pre-cancerous phenotype
P-59Zoé S. Tóth
The full-length Stl repressor is required for efficient inhibition of mycobacterial dUTPase
P-60Zsuzsánna Réthi-Nagy
Correlation between virulence and cytotoxicity of multidrug-resistant bacteria in human cell models
P-61Katalin Kuffa
Side-specific cell surface biotinylation to analyze the apical-basolateral distribution and accessible regions of transmembrane proteins in polarized epithelial cells
P-62Richárd Kinter
The effect of fluorescent photoactive Hsp90 inhibitors on the metastatic properties of melanoma cells
P-63Anna Sánta
Analysis of disease-associated point mutations of the Shank1 PDZ domain
P-64Doa'a Al-u'datt
Nanoparticles-derived royal jelly exerts antidiabetic properties
P-65Eszter Nagy-Kanta
Structural investigation of the multivalent complex of the GKAP scaffold and LC8 hub protein
P-66Nikoletta Pfeiffer
Effect of olaparib on temozolomide-induced cell death
P-67Bálint Péterfia
Ensemble-based modeling using SAXS and NMR data of the Drebrin single alpha-helix
P-68Ammar Darwish
Silver-lipid nanoparticles shaped for targeted tumor therapy
P-69Mátyás Sámuel Szabó
Examining the molecular mechanisms of irradiation-induced myocardial damage
P-70Barbara Erdélyi-Furka
The cytoprotective effect of preimplantation factor on irradiation-induced cardiac cell injury
P-71Dóra Nógrádi-Halmi
Kynurenic acid protects cardiac cells against doxorubicin-induced cardiotoxicity
P-72Renáta Gáspár
Mechanism of kynurenic acid-derived protection against simulated ischemia/reperfusion-induced cardiac cell damage: investigation on the potential modulation of autophagy

Poster discussion I. (odd numbers)

29 August, 17:00

P-01Kristóf Gui
The analysis of the classical and extended synergy transcription programs in macrophages and in epithelial-like tumor cells in the presence and absence of the transcription factor BACH1
P-03Valentina Madár
Exploring multicellular growth of yeast
P-05Ankita Murmu
Intercellular communication and CD8+ T-cell trajectory analysis in ovarian cancer tissues
P-07Tamás Takács
Orthosteric inhibitors targeting SHP2: structural insights and challenges
P-09Nikolett Nagy
Moonlighting role for dUTPase: establishing a viable mammalian cell line with high uracil DNA levels
P-11András Zeke
Analyzing redox features of proteins based on AlphaFold2 models
P-13Péter Tóth
Cell sorting based method for identifying CRISPR knock-in clones
P-15Balázs Csoma
Prime editing: advancing the frontiers of genetic engineering
P-17Zsuzsanna Biczók
A study on the reduction of self-complementarity in the prime editing RNA
P-19Bálint Csörgő
Repurposing CRISPR-Cas3 systems for probing phage-host interactions
P-21Balázs Ligeti
ProkBERT: genomic language models for understanding the microbiome
P-23Csaba Kiss
Investigating the role of non-coding genetic variants in colorectal cancer through single-cell multiomics analysis
P-25Ágnes Becsei
Detecting uracil in DNA with nanopore sequencing
P-27Beáta Vértessy
Artificial Intelligence-based search for new enzymes to degrade polluting hydrocarbons
P-29Dániel Molnár
Antibacterial action of membrane-incising peptide lamellae
P-31Dávid Kovács
Triglyceride acyl length drives lipolysis and adipocyte metabolism
P-33Mihály Józsi
Functional characterization of complement Factor H CCP19-20 variants with a set of host-derived and microbial ligands
P-35János András Mótyán
Structure-based identification of interacting partners of the human retroviral-like aspartic protease 1 (ASPRV1)
P-37Kiarie Irene Wanjiru
Inhibition profiling of integrase strand-transfer inhibitors and the capsid inhibitor against HIV-2, and exploration of factors associated with viral latency
P-39Éva Gráczer
Dissecting the cellular effects of beta-actin mutations causing non-muscle actinopathies
P-41Mária Golda
Investigation of the substrate specificity of human retroviral-like aspartic protease 1 (ASPRV1)
P-43Kriszinta Rubina Vass
NMR structural analysis of the lipoyl domain of the hKGDHc-E2 protein
P-45Dávid Szakács
Interaction of complement C3b with factor H family proteins
P-47Dávid Szakács
Annexin A2 is a ligand for complement factor H, FHL-1 and FHR proteins
P-49Mónika Ágnes Szütsné Tóth
Structure-function coordination in the SALS protein
P-51Mónika Ágnes Szütsné Tóth
Structural analysis of the EB1 protein
P-53Mohamad Mahfood
Expression of myosin phosphatase in breast cancer
P-55Csaba Magyar
MD simulation analysis of heterodimeric mutual synergistic folding proteins
P-57Rita Hirmondó
Do Mycobacteria really have no actin? Characterization of a potential Mbl protein
P-59Zoé S. Tóth
The full-length Stl repressor is required for efficient inhibition of mycobacterial dUTPase
P-61Katalin Kuffa
Side-specific cell surface biotinylation to analyze the apical-basolateral distribution and accessible regions of transmembrane proteins in polarized epithelial cells
P-63Anna Sánta
Analysis of disease-associated point mutations of the Shank1 PDZ domain
P-65Eszter Nagy-Kanta
Structural investigation of the multivalent complex of the GKAP scaffold and LC8 hub protein
P-67Bálint Péterfia
Ensemble-based modeling using SAXS and NMR data of the Drebrin single alpha-helix
P-69Mátyás Sámuel Szabó
Examining the molecular mechanisms of irradiation-induced myocardial damage
P-71Dóra Nógrádi-Halmi
Kynurenic acid protects cardiac cells against doxorubicin-induced cardiotoxicity

Poster discussion II. (even numbers)

30 August, 16:45

P-02Botond Engel
The mutagenic outcome of translesion replication at DNA adducts depends on polymerase choice
P-04Judit Tóth
dUTPase modulates mycobacterial homologous recombination through interaction with AdnAB
P-06Anna Zichy
Mapping and validation of structural variants in lung cancer for enhanced understanding of tumor development
P-08Eszter Vámos
The effect of trimethylamine, a metabolite of gut microbiota on the metabolic reprogramming of M1 macrophages
P-10Bence Farkas
The dominant form of the C1 inhibitor R444C variant causing type II hereditary angioedema is its covalent adduct with serum albumin explaining elevated levels
P-12Melinda Rostás
Loss of Mer receptor tyrosine kinase attenuates adipocyte hypertrophy and leads to enhanced thermogenesis in mice exposed to high-fat diet
P-14Kriszinta Rubina Vass
Recombinant production and characterization of human alpha-keto acid dehydrogenase complex subunits and their disease-relevant variants
P-16Ilka Keller
Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance
P-18Károly Hegedűs
Estimating efficiency of immunosuppressive therapy in heart transplant patients
P-20Eszter Holub
Key factors and consequences of drug induced genomic cytosine deamination
P-22Alexandra Sándor
Development of an induced pluripotent stem cell-based organoid model for investigating the molecular mechanisms of cerebellar ataxia
P-24Edit Szabó
Genetic variants of the human thiamine transporter (SLC19A3, THTR2) - potential relevance in type 2 diabetes mellitus
P-26Katalin Vincze
Exploring the neurological impact of type 2 diabetes in induced pluripotent stem cell derived neuronal progenitors and neurons
P-28Hédi Maczelka
Developing a novel endothelial dysfunction model using pluripotent stem cell-derived endothelial cells for extracellular matrix recellularisation
P-30Zita Bognár
Effect of Desethylamiodarone on mitochondrial mechanisms in breast cancer cell lines
P-32Ádám Ungvári
Myosin phosphatase promotes insulin-senitizing mechanisms in C2C12 muscle cells
P-34Viktória Jenei
Immunological characterization the different forms of necrotic cell death
P-36Renáta Bíró
ARHGAP25 has an anti-inflammatory role in the imiquimod-induced psoriasis mouse model
P-38Bálint Jezsó
Phase separation and cytoplasmic granulation by single-stranded DNA binding protein 1 (SSB1) delineate new mechanisms of cellular stress response
P-40Zoltán Ódor
Utilizing NanoFlare gold nanoparticles for dynamic monitoring of gene expression and cellular differentiation in colorectal cancer cells
P-42Viktória Tisza
CHD1 deletion in prostate cancer and its impact on PARP inhibitor sensitivity
P-44Petra Körmendi
Crosstalk of LKB1- and PKA-dependent signaling pathways in the regulation of hepatocyte polarity
P-46Seo Mizuki
Transferrin receptor-mediated iron uptake is required for thermogenic activation in human cervical derived adipocytes
P-48Mustafa Abdulkareem
Investigating the role of RNA binding in the cellular function of KMT2D
P-50Otília Tóth
Expression of dUTPase in mouse postnatal development
P-52Tamás Orbán
Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia
P-54Viktória Perey-Simon
Role and effect of uracil metabolism on zebrafish embryonic development
P-56Laura Vizkeleti
Functional understanding Septin9 intronic DNA methylation and its impact on colorectal cancer development and diagnosis
P-58Tamás Arányi
Hepatocyte-specific DNMT3A and DNMT3B knockout mice develop pre-cancerous phenotype
P-60Zsuzsánna Réthi-Nagy
Correlation between virulence and cytotoxicity of multidrug-resistant bacteria in human cell models
P-62Richárd Kinter
The effect of fluorescent photoactive Hsp90 inhibitors on the metastatic properties of melanoma cells
P-64Doa'a Al-u'datt
Nanoparticles-derived royal jelly exerts antidiabetic properties
P-66Nikoletta Pfeiffer
Effect of olaparib on temozolomide-induced cell death
P-68Ammar Darwish
Silver-lipid nanoparticles shaped for targeted tumor therapy
P-70Barbara Erdélyi-Furka
The cytoprotective effect of preimplantation factor on irradiation-induced cardiac cell injury
P-72Renáta Gáspár
Mechanism of kynurenic acid-derived protection against simulated ischemia/reperfusion-induced cardiac cell damage: investigation on the potential modulation of autophagy