Final Programme
Day 1 – 29 August 2024
| 15:00-15:10 | Opening |
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| 15:10-16:20 | Plenary session Congress Hall Chair: László Buday |
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| 15:10-16:00 | PL-1 György Keserű Mapping protein-protein interaction surfaces by photoactivable molecular fragments |
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| 16:00-16:20 | Bio Science award talk Áron Szabó LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models |
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| 16:20-16:35 | Company lecture of Kromat Kft. Éva Csősz Complex analysis of obesity and type 2 diabetes moonlights Olink's proximity extension assay as a method of choice in multiomics setup |
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| 16:35-16:50 | Company lecture of Molnár-Institute Imre Molnár Speeding up research in Biochemistry by Modeling HPLC |
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| 16:50-17:15 | Coffee break |
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| 17:00-18:00 | Poster discussion I. Jump to List of posters or Jump to poster discussion I. (odd number) |
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| 18:15- | Welcome reception |
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Day 2 – 30 August 2024
| 09:00-09:30 | Plenary session Congress Hall Chair: László Virág |
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| 09:00-09:30 | PL-2 József Tőzsér Structure, function, inhibition and resistance development of sars-cov-2 main protease (MPRO). what is common with retroviral proteases? |
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| 09:30-10:50 | Molecular signaling, cell-cell communication, cell death and differentiation
Chair: Zoltán Lipinszki |
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| O-01 Zoltán Lipinszki Exploring the Substrate Recognition Mechanism of Protein Phosphatase 4 Reveals Novel Functions of the Enzyme in DNA Damage Repair |
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| O-02 Krisztina Tar Can Manipulating Mitochondrial Dynamics Enhance Neuronal Differentiation? |
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| O-03 Endre Kristóf Upregulation of Inhibitor of DNA Binding 1 and 3 is important for efficient thermogeninc response in human adipocytes |
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| O-04 Virág Vas A comprehensive study from EMT regulation to cancer biomarker discovery: "Tyrosine kinase substrate with four SH3 domains" in focus |
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| 10:50-11:10 | Coffee Break |
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| 11:10-12:30 | Regulation of gene expression, regulatory RNA, epigenetics Chair: Mihály Kovács |
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| O-05 Mihály Kovács Subcellular rearrangements of bacterial single-stranded DNA binding (SSB) protein condensates indicate roles in stress response and cell proliferation |
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| O-06 Ágnes Tantos Competing endogenous RNA networks in different cancers |
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| O-07 Pantazi Vasiliki K63-linked ubiquitylation of RNAPII in response to DNA Double-Strand Breaks drives repair regulation |
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| O-08 Jacksi Mevan The role of EZH2 in TKS4-deficient colorectal carcinoma cells |
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| 12:30-13:30 | Lunch |
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| 13:30-14:50 | Protein structure, function and modeling, proteomics Chair: Ferenc Erdődi |
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| O-09 Orsolya Tőke Pressure denaturation of proteins |
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| O-10 Zoltán Kónya Characterization and analysis of protein phosphatase-1 and -2A modulators identified by high throughput screening |
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| O-11 Boglárka Zámbó Proteome-wide affinity survey of DNA-protein interactions: A case study on the erythroid-specific promoter of ATP2B4 gene and GATA1 mutations |
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| O-12 Gergő Gógl The non catalytic epsilon DNA polymerase subunit is an NPF motif recognition protein |
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| 14:50-15:10 | Coffee Break |
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| 15:10-16:30 | Bioinformatics, synthetic biology, genome engineering, biotechnology Chair: Zoltán Ivics |
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| O-13 Zoltán Ivics Advances in non-viral engineering of therapeutic cells with the Sleeping Beauty transposon system |
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| O-14 Orsolya Kapuy Re-wiring the AMPK-ULK1 regulatory connection at the service of periodic autophagy induction |
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| O-15 Regina Martinek Comprehensive investigation of the mutagenic potential of six pesticides classified by IARC as probably carcinogenic to humans |
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| O-16 István Hajdú Beta secretase 1 Recruits Amyloid beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta¬amyloid Plaque Formation |
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| 16:30-16:45 | Introduction of the FEBS Junior Section Hungary Chair: Virág Vas |
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| 16:45-18:00 | Poster discussion II. Jump to List of posters or Jump to poster discussion II (even number) |
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| 18:00- | Gala dinner | |
Day 3 – 31 August 2024
| 09:00-10:40 | Molecular basis of disease and therapy, stem cells, immunity and inflammation
Chair: Zsuzsanna Izsvák |
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| O-17 Zsuzsanna Izsvák HERVHLin protects human genome from mutagenic retroelements by rewiring the conserved LIN28A/let7 pathway in the early embryo |
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| O-18 Flóra Szeri Alkaline phosphatase activity correlates with circulatory mineralization factors upon aging in mice and human |
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| O-19 Rini Arianti Solute carrier transporters-mediated amino acids uptake is essential for thermogenic activation of human primary adipocytes |
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| O-20 Andrea Kocsis SARS-CoV-2 Nucleocapsid Protein Is Not Responsible for the Over-Activation of Complement Lectin Pathway |
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| O-21 Yousif Qais Muhsin Al-Khafaji Short-term thiamine deficiency altered transcriptomic profile of human deep cervical-derived adipocytes |
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| 10:40-11:00 | Coffee Break |
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| 11:00-12:20 | Translational medicine & Lipids and membranes Chair: György Vereb |
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| O-22 György Vereb Chimeric antigen receptors (CAR) in the treatment of solid tumors: lessons from HER2+ preclinical models |
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| O-23 József Prechl A truly quantitative antibody serological assay utilizing double-titration on antigen microspots |
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| O-24 Mohammed Maki Anaerobic glycolysis and MCT1inhibition via diclofenac lead to tumorigenesis regression, ROS accumulation through links intracellular acidification and OXPH in K562 erythroleukemia |
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| O-25 Tibor Pankotai Proteogenomics reveals varying levels of intra-patient heterogeneity in melanoma metastases |
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| 12:20 | Closing | |
| 12:40- | Farewell Lunch |
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List of posters
| P-01 | Kristóf Gui The analysis of the classical and extended synergy transcription programs in macrophages and in epithelial-like tumor cells in the presence and absence of the transcription factor BACH1 |
| P-02 | Botond Engel The mutagenic outcome of translesion replication at DNA adducts depends on polymerase choice |
| P-03 | Valentina Madár Exploring multicellular growth of yeast |
| P-04 | Judit Tóth dUTPase modulates mycobacterial homologous recombination through interaction with AdnAB |
| P-05 | Ankita Murmu Intercellular communication and CD8+ T-cell trajectory analysis in ovarian cancer tissues |
| P-06 | Anna Zichy Mapping and validation of structural variants in lung cancer for enhanced understanding of tumor development |
| P-07 | Tamás Takács Orthosteric inhibitors targeting SHP2: structural insights and challenges |
| P-08 | Eszter Vámos The effect of trimethylamine, a metabolite of gut microbiota on the metabolic reprogramming of M1 macrophages |
| P-09 | Nikolett Nagy Moonlighting role for dUTPase: establishing a viable mammalian cell line with high uracil DNA levels |
| P-10 | Bence Farkas The dominant form of the C1 inhibitor R444C variant causing type II hereditary angioedema is its covalent adduct with serum albumin explaining elevated levels |
| P-11 | András Zeke Analyzing redox features of proteins based on AlphaFold2 models |
| P-12 | Melinda Rostás Loss of Mer receptor tyrosine kinase attenuates adipocyte hypertrophy and leads to enhanced thermogenesis in mice exposed to high-fat diet |
| P-13 | Péter Tóth Cell sorting based method for identifying CRISPR knock-in clones |
| P-14 | Kriszinta Rubina Vass Recombinant production and characterization of human alpha-keto acid dehydrogenase complex subunits and their disease-relevant variants |
| P-15 | Balázs Csoma Prime editing: advancing the frontiers of genetic engineering |
| P-16 | Ilka Keller Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance |
| P-17 | Zsuzsanna Biczók A study on the reduction of self-complementarity in the prime editing RNA |
| P-18 | Károly Hegedűs Estimating efficiency of immunosuppressive therapy in heart transplant patients |
| P-19 | Bálint Csörgő Repurposing CRISPR-Cas3 systems for probing phage-host interactions |
| P-20 | Eszter Holub Key factors and consequences of drug induced genomic cytosine deamination |
| P-21 | Balázs Ligeti ProkBERT: genomic language models for understanding the microbiome |
| P-22 | Alexandra Sándor Development of an induced pluripotent stem cell-based organoid model for investigating the molecular mechanisms of cerebellar ataxia |
| P-23 | Csaba Kiss Investigating the role of non-coding genetic variants in colorectal cancer through single-cell multiomics analysis |
| P-24 | Edit Szabó Genetic variants of the human thiamine transporter (SLC19A3, THTR2) - potential relevance in type 2 diabetes mellitus |
| P-25 | Ágnes Becsei Detecting uracil in DNA with nanopore sequencing |
| P-26 | Katalin Vincze Exploring the neurological impact of type 2 diabetes in induced pluripotent stem cell derived neuronal progenitors and neurons |
| P-27 | Beáta Vértessy Artificial Intelligence-based search for new enzymes to degrade polluting hydrocarbons |
| P-28 | Hédi Maczelka Developing a novel endothelial dysfunction model using pluripotent stem cell-derived endothelial cells for extracellular matrix recellularisation |
| P-29 | Dániel Molnár Antibacterial action of membrane-incising peptide lamellae |
| P-30 | Zita Bognár Effect of Desethylamiodarone on mitochondrial mechanisms in breast cancer cell lines |
| P-31 | Dávid Kovács Triglyceride acyl length drives lipolysis and adipocyte metabolism |
| P-32 | Ádám Ungvári Myosin phosphatase promotes insulin-senitizing mechanisms in C2C12 muscle cells |
| P-33 | Mihály Józsi Functional characterization of complement Factor H CCP19-20 variants with a set of host-derived and microbial ligands |
| P-34 | Viktória Jenei Immunological characterization the different forms of necrotic cell death |
| P-35 | János András Mótyán Structure-based identification of interacting partners of the human retroviral-like aspartic protease 1 (ASPRV1) |
| P-36 | Renáta Bíró ARHGAP25 has an anti-inflammatory role in the imiquimod-induced psoriasis mouse model |
| P-37 | Kiarie Irene Wanjiru Inhibition profiling of integrase strand-transfer inhibitors and the capsid inhibitor against HIV-2, and exploration of factors associated with viral latency |
| P-38 | Bálint Jezsó Phase separation and cytoplasmic granulation by single-stranded DNA binding protein 1 (SSB1) delineate new mechanisms of cellular stress response |
| P-39 | Éva Gráczer Dissecting the cellular effects of beta-actin mutations causing non-muscle actinopathies |
| P-40 | Zoltán Ódor Utilizing NanoFlare gold nanoparticles for dynamic monitoring of gene expression and cellular differentiation in colorectal cancer cells |
| P-41 | Mária Golda Investigation of the substrate specificity of human retroviral-like aspartic protease 1 (ASPRV1) |
| P-42 | Viktória Tisza CHD1 deletion in prostate cancer and its impact on PARP inhibitor sensitivity |
| P-43 | Kriszinta Rubina Vass NMR structural analysis of the lipoyl domain of the hKGDHc-E2 protein |
| P-44 | Petra Körmendi Crosstalk of LKB1- and PKA-dependent signaling pathways in the regulation of hepatocyte polarity |
| P-45 | Dávid Szakács Interaction of complement C3b with factor H family proteins |
| P-46 | Seo Mizuki Transferrin receptor-mediated iron uptake is required for thermogenic activation in human cervical derived adipocytes |
| P-47 | Dávid Szakács Annexin A2 is a ligand for complement factor H, FHL-1 and FHR proteins |
| P-48 | Mustafa Abdulkareem Investigating the role of RNA binding in the cellular function of KMT2D |
| P-49 | Mónika Ágnes Szütsné Tóth Structure-function coordination in the SALS protein |
| P-50 | Otília Tóth Expression of dUTPase in mouse postnatal development |
| P-51 | Mónika Ágnes Szütsné Tóth Structural analysis of the EB1 protein |
| P-52 | Tamás Orbán Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia |
| P-53 | Mohamad Mahfood Expression of myosin phosphatase in breast cancer |
| P-54 | Viktória Perey-Simon Role and effect of uracil metabolism on zebrafish embryonic development |
| P-55 | Csaba Magyar MD simulation analysis of heterodimeric mutual synergistic folding proteins |
| P-56 | Laura Vizkeleti Functional understanding Septin9 intronic DNA methylation and its impact on colorectal cancer development and diagnosis |
| P-57 | Rita Hirmondó Do Mycobacteria really have no actin? Characterization of a potential Mbl protein |
| P-58 | Tamás Arányi Hepatocyte-specific DNMT3A and DNMT3B knockout mice develop pre-cancerous phenotype |
| P-59 | Zoé S. Tóth The full-length Stl repressor is required for efficient inhibition of mycobacterial dUTPase |
| P-60 | Zsuzsánna Réthi-Nagy Correlation between virulence and cytotoxicity of multidrug-resistant bacteria in human cell models |
| P-61 | Katalin Kuffa Side-specific cell surface biotinylation to analyze the apical-basolateral distribution and accessible regions of transmembrane proteins in polarized epithelial cells |
| P-62 | Richárd Kinter The effect of fluorescent photoactive Hsp90 inhibitors on the metastatic properties of melanoma cells |
| P-63 | Anna Sánta Analysis of disease-associated point mutations of the Shank1 PDZ domain |
| P-64 | Doa'a Al-u'datt Nanoparticles-derived royal jelly exerts antidiabetic properties |
| P-65 | Eszter Nagy-Kanta Structural investigation of the multivalent complex of the GKAP scaffold and LC8 hub protein |
| P-66 | Nikoletta Pfeiffer Effect of olaparib on temozolomide-induced cell death |
| P-67 | Bálint Péterfia Ensemble-based modeling using SAXS and NMR data of the Drebrin single alpha-helix |
| P-68 | Ammar Darwish Silver-lipid nanoparticles shaped for targeted tumor therapy |
| P-69 | Mátyás Sámuel Szabó Examining the molecular mechanisms of irradiation-induced myocardial damage |
| P-70 | Barbara Erdélyi-Furka The cytoprotective effect of preimplantation factor on irradiation-induced cardiac cell injury |
| P-71 | Dóra Nógrádi-Halmi Kynurenic acid protects cardiac cells against doxorubicin-induced cardiotoxicity |
| P-72 | Renáta Gáspár Mechanism of kynurenic acid-derived protection against simulated ischemia/reperfusion-induced cardiac cell damage: investigation on the potential modulation of autophagy |
Poster discussion I. (odd numbers)
29 August, 17:00
| P-01 | Kristóf Gui The analysis of the classical and extended synergy transcription programs in macrophages and in epithelial-like tumor cells in the presence and absence of the transcription factor BACH1 |
| P-03 | Valentina Madár Exploring multicellular growth of yeast |
| P-05 | Ankita Murmu Intercellular communication and CD8+ T-cell trajectory analysis in ovarian cancer tissues |
| P-07 | Tamás Takács Orthosteric inhibitors targeting SHP2: structural insights and challenges |
| P-09 | Nikolett Nagy Moonlighting role for dUTPase: establishing a viable mammalian cell line with high uracil DNA levels |
| P-11 | András Zeke Analyzing redox features of proteins based on AlphaFold2 models |
| P-13 | Péter Tóth Cell sorting based method for identifying CRISPR knock-in clones |
| P-15 | Balázs Csoma Prime editing: advancing the frontiers of genetic engineering |
| P-17 | Zsuzsanna Biczók A study on the reduction of self-complementarity in the prime editing RNA |
| P-19 | Bálint Csörgő Repurposing CRISPR-Cas3 systems for probing phage-host interactions |
| P-21 | Balázs Ligeti ProkBERT: genomic language models for understanding the microbiome |
| P-23 | Csaba Kiss Investigating the role of non-coding genetic variants in colorectal cancer through single-cell multiomics analysis |
| P-25 | Ágnes Becsei Detecting uracil in DNA with nanopore sequencing |
| P-27 | Beáta Vértessy Artificial Intelligence-based search for new enzymes to degrade polluting hydrocarbons |
| P-29 | Dániel Molnár Antibacterial action of membrane-incising peptide lamellae |
| P-31 | Dávid Kovács Triglyceride acyl length drives lipolysis and adipocyte metabolism |
| P-33 | Mihály Józsi Functional characterization of complement Factor H CCP19-20 variants with a set of host-derived and microbial ligands |
| P-35 | János András Mótyán Structure-based identification of interacting partners of the human retroviral-like aspartic protease 1 (ASPRV1) |
| P-37 | Kiarie Irene Wanjiru Inhibition profiling of integrase strand-transfer inhibitors and the capsid inhibitor against HIV-2, and exploration of factors associated with viral latency |
| P-39 | Éva Gráczer Dissecting the cellular effects of beta-actin mutations causing non-muscle actinopathies |
| P-41 | Mária Golda Investigation of the substrate specificity of human retroviral-like aspartic protease 1 (ASPRV1) |
| P-43 | Kriszinta Rubina Vass NMR structural analysis of the lipoyl domain of the hKGDHc-E2 protein |
| P-45 | Dávid Szakács Interaction of complement C3b with factor H family proteins |
| P-47 | Dávid Szakács Annexin A2 is a ligand for complement factor H, FHL-1 and FHR proteins |
| P-49 | Mónika Ágnes Szütsné Tóth Structure-function coordination in the SALS protein |
| P-51 | Mónika Ágnes Szütsné Tóth Structural analysis of the EB1 protein |
| P-53 | Mohamad Mahfood Expression of myosin phosphatase in breast cancer |
| P-55 | Csaba Magyar MD simulation analysis of heterodimeric mutual synergistic folding proteins |
| P-57 | Rita Hirmondó Do Mycobacteria really have no actin? Characterization of a potential Mbl protein |
| P-59 | Zoé S. Tóth The full-length Stl repressor is required for efficient inhibition of mycobacterial dUTPase |
| P-61 | Katalin Kuffa Side-specific cell surface biotinylation to analyze the apical-basolateral distribution and accessible regions of transmembrane proteins in polarized epithelial cells |
| P-63 | Anna Sánta Analysis of disease-associated point mutations of the Shank1 PDZ domain |
| P-65 | Eszter Nagy-Kanta Structural investigation of the multivalent complex of the GKAP scaffold and LC8 hub protein |
| P-67 | Bálint Péterfia Ensemble-based modeling using SAXS and NMR data of the Drebrin single alpha-helix |
| P-69 | Mátyás Sámuel Szabó Examining the molecular mechanisms of irradiation-induced myocardial damage |
| P-71 | Dóra Nógrádi-Halmi Kynurenic acid protects cardiac cells against doxorubicin-induced cardiotoxicity |
Poster discussion II. (even numbers)
30 August, 16:45
| P-02 | Botond Engel The mutagenic outcome of translesion replication at DNA adducts depends on polymerase choice |
| P-04 | Judit Tóth dUTPase modulates mycobacterial homologous recombination through interaction with AdnAB |
| P-06 | Anna Zichy Mapping and validation of structural variants in lung cancer for enhanced understanding of tumor development |
| P-08 | Eszter Vámos The effect of trimethylamine, a metabolite of gut microbiota on the metabolic reprogramming of M1 macrophages |
| P-10 | Bence Farkas The dominant form of the C1 inhibitor R444C variant causing type II hereditary angioedema is its covalent adduct with serum albumin explaining elevated levels |
| P-12 | Melinda Rostás Loss of Mer receptor tyrosine kinase attenuates adipocyte hypertrophy and leads to enhanced thermogenesis in mice exposed to high-fat diet |
| P-14 | Kriszinta Rubina Vass Recombinant production and characterization of human alpha-keto acid dehydrogenase complex subunits and their disease-relevant variants |
| P-16 | Ilka Keller Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance |
| P-18 | Károly Hegedűs Estimating efficiency of immunosuppressive therapy in heart transplant patients |
| P-20 | Eszter Holub Key factors and consequences of drug induced genomic cytosine deamination |
| P-22 | Alexandra Sándor Development of an induced pluripotent stem cell-based organoid model for investigating the molecular mechanisms of cerebellar ataxia |
| P-24 | Edit Szabó Genetic variants of the human thiamine transporter (SLC19A3, THTR2) - potential relevance in type 2 diabetes mellitus |
| P-26 | Katalin Vincze Exploring the neurological impact of type 2 diabetes in induced pluripotent stem cell derived neuronal progenitors and neurons |
| P-28 | Hédi Maczelka Developing a novel endothelial dysfunction model using pluripotent stem cell-derived endothelial cells for extracellular matrix recellularisation |
| P-30 | Zita Bognár Effect of Desethylamiodarone on mitochondrial mechanisms in breast cancer cell lines |
| P-32 | Ádám Ungvári Myosin phosphatase promotes insulin-senitizing mechanisms in C2C12 muscle cells |
| P-34 | Viktória Jenei Immunological characterization the different forms of necrotic cell death |
| P-36 | Renáta Bíró ARHGAP25 has an anti-inflammatory role in the imiquimod-induced psoriasis mouse model |
| P-38 | Bálint Jezsó Phase separation and cytoplasmic granulation by single-stranded DNA binding protein 1 (SSB1) delineate new mechanisms of cellular stress response |
| P-40 | Zoltán Ódor Utilizing NanoFlare gold nanoparticles for dynamic monitoring of gene expression and cellular differentiation in colorectal cancer cells |
| P-42 | Viktória Tisza CHD1 deletion in prostate cancer and its impact on PARP inhibitor sensitivity |
| P-44 | Petra Körmendi Crosstalk of LKB1- and PKA-dependent signaling pathways in the regulation of hepatocyte polarity |
| P-46 | Seo Mizuki Transferrin receptor-mediated iron uptake is required for thermogenic activation in human cervical derived adipocytes |
| P-48 | Mustafa Abdulkareem Investigating the role of RNA binding in the cellular function of KMT2D |
| P-50 | Otília Tóth Expression of dUTPase in mouse postnatal development |
| P-52 | Tamás Orbán Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia |
| P-54 | Viktória Perey-Simon Role and effect of uracil metabolism on zebrafish embryonic development |
| P-56 | Laura Vizkeleti Functional understanding Septin9 intronic DNA methylation and its impact on colorectal cancer development and diagnosis |
| P-58 | Tamás Arányi Hepatocyte-specific DNMT3A and DNMT3B knockout mice develop pre-cancerous phenotype |
| P-60 | Zsuzsánna Réthi-Nagy Correlation between virulence and cytotoxicity of multidrug-resistant bacteria in human cell models |
| P-62 | Richárd Kinter The effect of fluorescent photoactive Hsp90 inhibitors on the metastatic properties of melanoma cells |
| P-64 | Doa'a Al-u'datt Nanoparticles-derived royal jelly exerts antidiabetic properties |
| P-66 | Nikoletta Pfeiffer Effect of olaparib on temozolomide-induced cell death |
| P-68 | Ammar Darwish Silver-lipid nanoparticles shaped for targeted tumor therapy |
| P-70 | Barbara Erdélyi-Furka The cytoprotective effect of preimplantation factor on irradiation-induced cardiac cell injury |
| P-72 | Renáta Gáspár Mechanism of kynurenic acid-derived protection against simulated ischemia/reperfusion-induced cardiac cell damage: investigation on the potential modulation of autophagy |