Program
Day 1, Wednesday, Aug 26th
| 14:00-14:40 | Opening and FEBS National Lecture Chair: Mihály Kovács |
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| 14:00-14:10 Mihály Kovács, László Csernoch, György Panyi Opening | ||
| 14:10-14:40 Michele Vendruscolo (University of Cambridge) Drug design for undruggable targets using AI | ||
| 14:40-16:10 | Computational biology, intrinsically disordered proteins, systems biology Chair: Zsuzsanna Dosztányi |
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| 14:40-15:00 Xavier Salvatella (IRB Barcelona) Kinetic stabilization of transcription factor condensates by sequence biases that increase helical propensity | ||
| 15:00-15:20 Markus Zweckstetter (German Center For Neurodegenerative Diseases) Decoding conformational heterogeneity across disordered proteomes | ||
| 15:20-15:35 Gábor Erdős (Eötvös Loránd University) Zero-shot prediction of thermodynamic properties of proteins | ||
| 15:35-15:50 Krisztina Tar (University of Debrecen) The contribution of gastrointestinal motility changes to weight loss in patients with HD | ||
| 15:50-16:10 Zsuzsanna Dosztányi (Eötvös Loránd University) Exploring linear motif-mediated interaction networks | ||
| 16:10-18:00 | Poster discussion I. Jump to List of posters or Jump to poster discussion I. (odd number) |
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| 18:00- | Welcome reception |
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Day 2, Thursday, Aug 27th
| 9:00-10:00 | Award lectures Chair: Beáta Lontay |
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| 9:00-9:20 László Virág (Tankó Béla Award) TBA | ||
| 9:20-9:40 Viktor Dombrádi (Tankó Béla Lifetime Achievement Award) TBA | ||
| 9:40-9:50 Hamidreza Mianesaz (Bio-Science Award) (University of Debrecen) Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways | ||
| 9:50-10:00 Mihály Kovács, Anita Alexa, Ilka Keller, Orsolya Németh-Szatmári (Biokémia 50 Award) | ||
| 10:00-10:30 | Coffee Break |
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| 10:30-12:00 | Molecular signaling, cell-cell communication, cell death and differentiation Chair: Anikó Keller-Pintér |
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| 10:30-10:50 Agnieszka Chacinska (Polish Academy of Sciences) Regulation of mitochondrial protein import in human cells | ||
| 10:50-11:10 László Hunyady (HUN-REN Research Centre For Natural Sciences) Roles of arrestin proteins in the regulation of receptor function | ||
| 11:10-11:25 Szilvia Benkő (University of Debrecen) Intracellular pattern recognition nod-like receptors in skeletal muscle cells | ||
| 11:25-11:40 Edina Szabó-Meleg (University of Pécs) Membrane nanotubes as pathways for viral dissemination and intercellular cargo transfer | ||
| 11:40-12:00 József Mihály (HUN-REN Biological Research Centre) Flightless I and LRRFIP work together to regulate lateral growth of the sarcomeres in Drosophila | ||
| 12:00-13:15 | Lunch |
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| 13:15-15:15 | Genome organization and engineering, gene expression, epigenetics Chair: Dávid Szüts |
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| 13:15-13:35 George Garinis (Imbb-Forth and The University of Crete) DNA damage and innate immune signalling in health and disease | ||
| 13:35-13:55 David Rueda (Imperial College London) Dynamic control of chromatin architecture and DNA resolution | ||
| 13:55-14:15 Gergely Nagy (University of Debrecen) Lineage-determining transcription factor-driven promoters regulate cell type-specific macrophage gene expression | ||
| 14:15-14:35 Lóránt Székvölgyi (University of Debrecen) Mitochondrial topoisomerase 1 (TOP1MT) rs2293925 is an enhancer-active SNP that shapes mitochondrial R-Loop dynamics | ||
| 14:35-14:55 Ágnes Tantos (HUN-REN Research Centre For Natural Sciences) Exploring non-histone lysine methylation in the human proteome | ||
| 14:55-15:15 Iván Uray (University of Debrecen) Epigenetic modulation of the mammary extracellular matrix by the zymogen granule protein 16B (ZG16B) | ||
| 15:15-15:45 | Coffee Break |
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| 15:45-17:45 | Protein structure, function and modeling, proteomics Chair: Éva Csősz |
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| 15:45-16:05 Fernando Corrales (National Center For Biotechnology) Proteomic Insights into the molecular mechanisms of chronic cholestatic liver disease: a framework for clinical applications | ||
| 16:05-16:20 Arnon Henn (Technion-Israel Institute of Technology) Myosin19 molecular motor is functionally tailor-made for orchestrating mitochondrial transport and powering cellular migration | ||
| 16:20-16:35 Michal Wasilewski (Polish Academy of Sciences) New tools to study the localization and biogenesis of mitochondrial proteins | ||
| 16:35-16:50 János Mótyán (University of Debrecen) Structure and specificity of human retroviral-like aspartic protease 1 (ASPRV1) | ||
| 16:50-17:05 Andrea Bodor (Eötvös Loránd University) NMR spectroscopy in structural biology | ||
| 17:05-17:25 Keir Neuman (National Institutes of Health) Direct observation topoisomerase conformational dynamics | ||
| 17:25-17:45 Sandra Macedo-Ribeiro (Universidade Do Porto) Nanobodies as tools to interrogate flexible protein targets in neurodegenerative diseases | ||
| 16:45-18:00 | Poster discussion II. Jump to List of posters or Jump to poster discussion II (even number) |
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| 18:00- | Gala dinner | |
Day 3, Friday, Aug 28th
| 9:00-10:40 | Molecular basis of disease and therapy Chair: Ferenc Gallyas |
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| 9:00-9:15 Péter Bay (University of Debrecen) Adrenalin overproduction in breast cancer patients and its sequelae | ||
| 9:15-9:30 Éva Csősz (University of Debrecen) Circulating biomarkers and molecular heterogeneity identified by machine learning in obesity and type 2 diabetes | ||
| 9:30-9:45 Agnieszka Robaszkiewicz (University of Lodz) Redox adaptation underlies survival of chemotherapy-resistant polyploid giant cancer cells revealed by single-cell transcriptomics | ||
| 9:45-10:00 Péter Nagy (National Institute of Oncology) Cysteine metabolism in cancer | ||
| 10:00-10:20 László Nagy (Johns Hopkins University School of Medicine) BACH1 acts as a pioneer repressor to enable macrophage plasticity and adaptation across tissues and inflammatory contexts | ||
| 10:20-10:40 Veerle Janssens (University of Leuven) Protein phosphatase 2A: a structural and functional signaling centipede with roles in disease | ||
| 10:40-11:00 | Coffee Break |
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| 11:00-12:30 | Translational research, medicinal biochemistry, drug development Chair: György Keserű |
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| 11:00-11:30 Rob Leurs (Vrije University) Photopharmacology: towards new tools for spatial-temporal modulation of biology | ||
| 11:30-11:50 András Nagy (HUN-REN Research Centre For Natural Sciences) Engineering immune evasion in pluripotent stem cells with safecell tumor control for universal cell lines | ||
| 11:50-12:10 András Málnási-Csizmadia (Eötvös Loránd University) CLN-2501, the first-in-class capillary-selective vasorelaxant restores microvascular reperfusion after acute myocardial infarction | ||
| 12:10-12:30 Ferenc Gallyas (University of Pécs) Cardioprotective effects of red wine polyphenols | ||
| 12:30-14:00 | Mechanistic insights and applied platforms in biotechnology Chair: Ágota Apáti |
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| 12:30-12:50 Zsuzsanna Izsvák (The Max Delbrück Center) Replication-coupled DNA topology guides Sleeping Beauty integration and enables programmable retuning of insertion landscapes | ||
| 12:50-13:10 Attila Csikász-Nagy (Pázmány Péter Catholic University) Quantitative analysis of spatial growth and interactions in yeast colonies under variable environments | ||
| 13:10-13:30 Zeljko Popović (University of Novi Sad) Biochemistry behind diapause - insects as a promising source of new pharmaceuticals | ||
| 13:30-13:45 Bernadett Kolozsvári (Bio-Science Ltd) From isolation to insight — power your extracellular vesicles research | ||
| 13:45-14:00 Katalin Vincze (HUN-REN Research Centre For Natural Sciences) Molecular and Pharmacological Characterization of α7 Nicotinic Acetylcholine Receptors in hiPSC-Derived Dentate Gyrus Granule Cells | ||
| 14:00 | Closing Chair: Mihály Kovács |
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| 14:15- | Farewell Lunch |
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List of posters
| P-01 | Ximena Aixa Castro Naser (University of Padova) A Shared Vocabulary for Disordered Proteins and Condensates |
| P-02 | Andrea Guba (University of Debrecen) A Method Based On Liquid Chromatography And Mass Spectrometry For The Quantitative Determination of Adenine Nucleotides In Bacterial Samples |
| P-03 | Norbert Deutsch (Eötvös Loránd University) Variant Effect Predictors Show Systematic Bias in Intrinsically Disordered Regions |
| P-04 | Zhangzheng Wang (University of Debrecen) INtegrative Proteomics And Mendelian Randomization Identify Casual Biomarkers For Non-Traumatic Osteonecrosis of The Femoral Head |
| P-05 | Arpan Ghosh (Eötvös Loránd University) Computational tools for proteome-wide prediction of IDR-mediated interactions |
| P-06 | Richárd Hornyák (Eötvös Loránd University) Benchmarking Computational Methods to Characterize the Conformational Ensembles of Intrinsically Disordered Proteins |
| P-07 | Rita Pancsa (HUN-REN Research Centre For Natural Sciences) Reliable prediction of short linear motifs in the human proteome |
| P-08 | Szilvia Dudla (HUN-REN Research Centre For Natural Sciences) Structural Analysis of Unilamellar Phospholipid Vesicles with Small-Angle X-ray Scattering and Molecular Dynamics Simulations |
| P-09 | Mustafa Abdulakreem (HUN-REN Research Centre For Natural Sciences) Investigating the role of RNA binding in the cellular function of KMT2D |
| P-10 | Éva Kereszturi (Semmelweis University) Fatty Acid-Induced Remodeling of the Hepatic miRNA Landscape: miR-1269a-Mediated Regulation of H6PD |
| P-11 | Dóra Csige (University of Debrecen) Transcriptomic profiling identifies disease-specific miRNA-mRNA regulatory networks in systemic sclerosis |
| P-12 | Dóra Nagy-Bojcsuk (University of Debrecen) CpG content contributes to tissue-resident macrophage enhancer selection |
| P-13 | Edina Erdős (HUN-REN Biological Research Centre) IL-4-activated STAT6 priming shapes context-dependent transcriptional responses in macrophages |
| P-14 | Dzsenifer Török (HUN-REN Biological Research Centre) WRNIP1 and BLM cooperate in i-motif processing |
| P-15 | Viktória Kátrán (Eötvös Loránd University) Breaking bonds, building droplets: how interface mutations affect phase separation in Escherichia coli single-stranded DNA-binding protein (EcSSB) |
| P-16 | Luca Gál (HUN-REN Research Centre For Natural Sciences) Systematic evaluation of the effect of PBS length on editing outcome in Prime Editing |
| P-17 | Péter Tóth (HUN-REN Research Centre For Natural Sciences) Development of a Reporter for the identification of CRISPR-Mediated HDR Knock-In Events in Coding Sequences |
| P-18 | Szvitlána Kusztro (University of Debrecen) The importance of thiamine availability in the thermogenic competency of human adipocytes |
| P-19 | Kyuseung Lee (University of Debrecen) PPARγ Agonist Rosiglitazone Induces Thermogenic Transcriptomic Profile of Human Adipocytes Carrying Fto Rs1421085 Obesity Risk-Free Alleles Not Affecting The Risk Allele Carriers |
| P-20 | Botond Csongrádi (University of Debrecen) Identification of plasma membrane-associated hsp90 melanoma-specific client proteins |
| P-21 | Richárd Kinter (University of Debrecen) Effects of fluorescent photoactive hsp90 inhibitors on the metastatic properties of melanoma cells |
| P-22 | Sabahat Gulzar (Polish Academy of Sciences) Altered Mitochondrial Dynamics and Calcium Homeostasis in Brain Endothelial Cells in Duchenne Muscular Dystrophy |
| P-23 | Mohamad Mahfood (University of Debrecen) Identification of miRNAs Regulating Myosin Phosphatase Expression in Breast Cancer |
| P-24 | Zoltán Palczert (Semmelweis University) The insulin receptor internalization is regulated by PCSK9 and diet |
| P-25 | Hossameldin Ali (University of Debrecen) Exploring the role of the proteasome activator PA200 in the decreased fertility of HD transgenic male mice |
| P-26 | Gabriella Orosz (Semmelweis University) Influence of common missense polymorphisms on the stability of the human SCD5B protein |
| P-27 | Seo Mizuki (University of Debrecen) Cytosolic aconitase 1 (ACO1) determines the thermogenic potential of human deep cervical area-derived adipocytes |
| P-28 | Viktória Lőrinczi (University of Debrecen) The extracellular myo-inositol enhances the thermogenic capacity of human sgbs adipocytes |
| P-29 | Dávid Kovács (University of Szeged) Chain length determines fatty acid metabolism in adipocytes |
| P-30 | Boglárka Juhász (University of Szeged) Investigating adipocyte differentiation in the breast cancer microenvironment |
| P-31 | Júlia Kollár (University of Szeged) Adipocyte lipid composition drives breast cancer cell invasion |
| P-32 | Olga Nagy (Center For Reproductive Medicine, Department of Obstetrics And Gynecology, Albert Szent-Györgyi Health Centre, University of Szeged, Hungary) Sperm dna integrity behind infertility: differential associations of single- and double-strand sperm dna breaks with male fertility parameters |
| P-33 | Emese Tóth (University of Debrecen) The role of catecholamines in breast cancer progression |
| P-34 | Job Kola () Stretch-induced regulation of CXCL1 expression during the development of ileus |
| P-35 | Dorottya Károlyi (Eötvös Loránd University) Fatty acid synthesis is critical for sustaining torc1 activity in malignant tumors |
| P-36 | Lili Fruzsina Balogh (University of Debrecen) Copine expression profiles in human epidermal melanocytes and melanoma cells |
| P-37 | Áron Zubánics-Nagy (Semmelweis University) Heterologous expression, purification and characterization of mitochondrial alpha-keto acid dehydrogenase complex subunits and their disease-relevant mutant variants |
| P-38 | Tibor Hajdú (University of Debrecen) THE SEPTIN7-soce axis is crucial for melanoma cell invasiveness |
| P-39 | Péter Deák (University of Pécs) Investigation of the effect of MIF tautomerase inhibitor TE-91 in M1 polarized macrophages |
| P-40 | János Pálinkás (Eötvös Loránd University) SSB1 links stress granule regulation to cellular stress responses and renal ischemia-reperfusion injury |
| P-41 | Kinga Kołacz-Milewska (University of Lodz) Single-cell-guided identification of early and late polyploid giant cancer cells reveals their essential dependence on thiol-recycling antioxidant systems |
| P-42 | József Tőzsér (University of Debrecen) Modified mRNA encoding SARS-CoV-2 Spike Protein Modulate Macrophage Polarization, Cytokine Production, and Phagocytic Activity |
| P-43 | Bettina Rákóczi (HUN-REN Biological Research Centre) Modulatory role of HSPB1 in Neuroinflammation and Glial Activation |
| P-44 | István Bohács (HUN-REN Biological Research Centre) Membrane lipid remodelling during intracellular thermogenesis: implications for cellular stress adaptation |
| P-45 | Melinda Tóth (HUN-REN Biological Research Centre) Heat shock proteins and thermal stress in the aging brain: Increased vulnerability and therapeutic opportunities |
| P-46 | Péter Tóth (University of Debrecen) Raman spectroscopy distinguishes HER2-positive breast cancer cell lines through lipid metabolic signatures |
| P-47 | Botond Engel (HUN-REN Research Centre For Natural Sciences) The role of polymerase ⍳ in chemotherapy- and smoking-induced mutagenesis |
| P-48 | Tibor Kovács (Eötvös Loránd University) The GTPase-activating protein TBC1D30 is a conserved negative regulator of Rab2A mediated lysosomal degradation |
| P-49 | Hédi Árva (University of Szeged) Investigation of gene expressional changes related to heart failure with preserved ejection fraction in rat |
| P-50 | Ilka Keller (University of Debrecen) Smoothelin-like protein 1 promotes decidualization of human endometrial stromal cells in in vitro PCOS model - TITKOSITOTT - |
| P-51 | Ádám Ungvári (University of Debrecen) SMTNL1 reverses impaired decidualization and inflammation under pcos-like conditions in human endometrial stromal cells - TITKOSITOTT - |
| P-52 | Petra Körmendi (HUN-REN Research Centre For Natural Sciences) Intracellular trafficking of the ABCG2 multidrug transporter – the role of recycling endosomes |
| P-53 | Rini Arianti (University of Debrecen) Revealing the criticial role of iron in the thermogenic gene regulation of human adipocytes |
| P-54 | Sarolta Tóth (Semmelweis University) The role of Plasma Membrane Ca²⁺-ATPase 4b in autophagy |
| P-55 | Albert Papp (University of Debrecen) Impared skeletal muscle regeneration in the absence of adenosine a2a receptor |
| P-56 | Loretta László (HUN-REN Research Centre For Natural Sciences) Tks4 invadosome protein is involved in the LLPS-driven signaling network |
| P-57 | Nóra Enyedi (University of Debrecen) Inhibition of L-type amino acid transporters (LATs) impairs thermogenesis in human cervical-derived adipocytes |
| P-58 | Zsófia Bodogán (University of Debrecen) Interplay of myosin phosphatase and protein phosphatase-2A in the EGCG/67LR signaling pathway |
| P-59 | Dorottya Vígh (University of Debrecen) Epirubicin sensitizes HER2+ breast cancer cells to the antitumor activity of chimeric antigen receptor-expressing macrophages |
| P-60 | Ahmad Ismael (University of Debrecen) STAT5-Mediated Regulation of the NLRP3 Inflammasome |
| P-61 | Hala Ahmad (University of Debrecen) ATRA Modulates Inflammasomes Expression and Function in Human Macrophage Subpopulations |
| P-62 | Fanni Balogh (University of Debrecen) Role of NOD-like receptors in human monocyte-derived mircroglia-like cells under hypoxia |
| P-63 | András Czajlik (Semmelweis University) Solution structure and dynamics of the lipoylated and non-lipoylated lipoyl domain in the dihydrolipoamide succinyltransferase (E2) subunit of the human alpha-ketoglutarate dehydrogenase complex |
| P-64 | Samara Mhana (University of Debrecen) Effect of mesotrypsinogen-specific mutations on human trypsinogen autoactivation |
| P-65 | Kinga Tibori (Semmelweis University) Effect of the most common missense variations on the human NADH cytochrome b5 oxidoreductase enzyme |
| P-66 | Villő Kocsis (Semmelweis University) Assessing HSD11B1 Missense Variants: Bridging In Silico Predictions and In Vitro Functional Analysis |
| P-67 | Ákos Harkai (Semmelweis University) Analysis of GbpC-aptamer binding using an AI-based approach |
| P-68 | Dávid Lepár (University of Szeged) Functional characterisation of the spermatoproteasome during spermatogenesis in Drosophila melanogaster |
| P-69 | Mansi Jain (University of Debrecen) Optimising the Sample Preparation Workflow for Mass Spectrometry Based Tear Proteomics |
| P-70 | Petra Magdolna Bertalan (University of Debrecen) Targeting antimicrobial and immunomodulatory peptides in human biofluids |
| P-71 | Moballegh Nasery Mahshid (University of Debrecen) Identification of an Immune-Related Signature for Pediatric Acute Lymphoblastic Leukemia |
| P-72 | Minh Ngoc Nguyen (University of Debrecen) Proteomic anaylsis of the surfaceome in human melanoma |
| P-73 | Gyula Hoffka (University of Debrecen) Computational insight into reaction mechanism and antiviral resistance development of SARS-CoV-2 main protease |
| P-74 | Alaa Rahim (University of Debrecen) RNA interactions of human neuronal transglutaminase |
| P-75 | Bernadett Juhász (Eötvös Loránd University) Exploring the LC8 proximal interactome using TurboID |
| P-76 | Patrik Horváth (Eötvös Loránd University) Disease-associated mutations alter interactions and condensation properties of human mitochondrial single-stranded DNA binding protein |
| P-77 | Babett Csordás (University of Pécs, Medical School) Investigation of the Interaction Between Myotrophin and Capping Protein in a Drosophila Model System |
| P-78 | Tamás Szaniszló (Eötvös Loránd University) Expanding the Role of LC8: A Central Player in the Ciliary-Centrosomal System |
| P-79 | Dorka Aszódy (Eötvös Loránd University) SLIM-mediated interactions connect LC8 to PML nuclear bodies |
| P-80 | Dalma Dojcsák (University of Miskolc) CRP-Associated Remodeling of the Serum and IgG N-Glycoproteome in Pediatric Appendicitis Revealed by MALDI-FTICR |
| P-81 | Péter Hunyadi (HUN-REN Tki) Unlocking the Hinge: A Conserved Proline Residue Mediates Long-Range Allosteric Coupling in AtABCB1 Transporter |
| P-82 | Tamara Teski (HUN-REN Research Centre For Natural Sciences) Functionally related internal fluctuations in human ileal bile acid-binding protein by high pressure NMR |
| P-83 | Márton Péter Nyiri (Eötvös Loránd University) Effect of plastic nanoparticles on the aggregation properties and cytotoxicity of amyloid-β peptide |
| P-84 | Benjamin Kovács (Eötvös Loránd University) Solution NMR studies of EcSSB protein: from disorder to phase separation |
| P-85 | Fanni Sebák (Eötvös Loránd University) Slow and fast timescale dynamics in the disordered N-terminal region of p53 in free form and in complex with S100P protein |
| P-86 | Yousif Al-Khafaji (University of Debrecen) Deferoxamine-mediated iron depletion prevented thermogenic activation in human cervical-derived adipocytes |
| P-87 | Emília Kovács (University of Debrecen) The role of thiamine transporters in thermogenesis of human adipocytes |
| P-88 | Kristóf Guy (University of Debrecen) Role of the iron-ferritin-ferroxidase axis in the progression of valvular mineralization: lysosomes to exosomes |
| P-89 | Enikő Tóth (University of Szeged) Tilorone Suppresses TGF-β–Driven Fibroblast Activation and Restores BMP–Smad1/5/8 Signaling: Implications for Laryngotracheal Fibrosis |
| P-90 | Vanja Tatić (University of Novi Sad) Combined wet lab and in silico analyses of insect haemolymph towards identification of biotechnologically applicable proteins |
| P-91 | Doaa Al-U'Datt (Jordan University of Science And Technology) Targeting Peptidylarginine Deiminase 4 to Mitigate Cardiac Fibrosis and Remodeling |
| P-92 | Emese Huber (University of Debrecen) Metabolic and pharmacological modulation of the molecular clock in human melanoma cells |
| P-93 | Norman Noel Tanner (University of Szeged) Sex differences in the metabolic effects of atorvastatin and metformin treatment in a diet-induced obesity mouse model |
| P-94 | Zoltán Kónya (University of Debrecen) Studying protein phosphatase-mediating drugs: In Vitro influences and the cellular effects |
| P-95 | Pálma Porrogi (Széchenyi István University) Inflammation and enzyme induction drive phenoconversion to a functional poor metabolizer state in CYP3A5*3/*3 carriers: Biochemical insights from antipsychotic polypharmacy |